Key result
Spontaneous tone in renal arteries is precipitated by age and hypertension, driven by reduced NO production and COX products activating EP-1 and TP receptors.
Spontaneous tone in renal arteries is precipitated by age and hypertension, involving reduced NO production and COX products activating EP-1 and TP receptors.
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Hypothesis-generating in aged hypertensive models; leaves open whether EP-1/TP targeting improves human renal outcomes.
Michel et al. (2007) studied Hypertension. Age and hypertension vs. Young and normotensive Wistar-Kyoto rats was evaluated on Spontaneous tone in renal arteries. Spontaneous tone in renal arteries is precipitated by age and hypertension, driven by reduced NO production and COX products activating EP-1 and TP receptors.
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