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December 1, 1996British Journal of PharmacologyOpen Access

Alterations of cyclo‐oxygenase products and NO in responses to angiotensin II of resistance arteries from the spontaneously hypertensive rat

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Population

Small mesenteric arteries from spontaneously hypertensive rats (SHR) and Wistar Kyoto (WKY) rats

Comparison

Angiotensin II exposure with various inhibitors… vs WKY rats vs SHR rats; vessels with vs without…

Design

Preclinical

Authors

SCSteyner F. CôrtesHospital de Santa MariaRARamaroson AndriantsitohainaVascular MedicineJSJ.C. StocletCentre National de la Recherche Scientifique

Discussion

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Implication

Hypothesis-generating for COX-NO balance in AII-exposed hypertensive arteries; should not yet change clinical practice.

Structured PICO

P
Population
Small mesenteric arteries from spontaneously hypertensive rats (SHR) and Wistar Kyoto (WKY) rats
I
Intervention
Angiotensin II (AII) exposure with various inhibitors (indomethacin 10(-5) M, GR32191 B 3 x 10(-6) M, L-NAME 10(-4) M) and endothelium removal
C
Comparator
WKY rats vs SHR rats; vessels with vs without functional endothelium
O
Outcome
Contractile responses to angiotensin II (sensitivity/pD2 and maximal contraction)surrogate

In spontaneously hypertensive rats, the enhanced contractile response to angiotensin II mediated by COX products is counterbalanced by increased endothelium-derived NO relaxation.

Cite This Study

Côrtes et al. (1996) studied this question.

synapsesocial.com/papers/6a856bcf425e2f70a4671757https://doi.org/10.1111/j.1476-5381.1996.tb16083.x

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prostaglandin H2 and thromboxane A2 are contractile factors in intrarenal arteries of spontaneously hypertensive rats.1992 · 67 citations
  2. 2Impaired endothelium-dependent relaxations in hypertensive resistance arteries involve cyclooxygenase pathway1990 · 182 citations
  3. 3Exaggerated renal vascular reactivity to angiotensin and thromboxane in young genetically hypertensive rats1990 · 92 citations
  4. 4Endothelial AT<sub>1</sub>–Mediated Release of Nitric Oxide Decreases Angiotensin II Contractions in Rat Carotid Artery1995 · 123 citations
  5. 5Differential pressor and renal vascular reactivity to angiotensin II in spontaneously hypertensive and Wistar-Kyoto rats.1987 · 27 citations