April 1, 1992Journal of Cardiovascular Pharmacology

Endothelial Dysfunction of Resistance Arteries of Spontaneously Hypertensive Rats

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Population

4-week-old spontaneously hypertensive rats (SHRs) and Wistar-Kyoto (WKY) rats

Comparison

Acetylcholine administration (10 to 10 M) to… vs WKY rat resistance arteries

Design

Preclinical

Authors

MJMichael JamesonUniversity of Wollongong JSJ. SkopecUniversity of Kansas Medical Center ADA. DiederichJohns Hopkins University

Discussion

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Implication

Highlights prostanoid-mediated contractions in SHR vessels; hypothesis-generating and leaves open human relevance.

Structured PICO

Population

4-week-old spontaneously hypertensive rats (SHRs) and Wistar-Kyoto (WKY) rats

Intervention

Acetylcholine (ACh) administration (10(-9) to 10(-5) M) to precontracted mesenteric and renal resistance arteries, with or without inhibitors (indomethacin, SQ 29548, 3-amino-1,2,4-triazole)

Comparator

WKY rat resistance arteries

Outcome

Endothelium-mediated relaxations and contractile responses in myographs and arteriographssurrogate

Endothelial dysfunction precedes the development of accelerated hypertension in spontaneously hypertensive rats, mediated by different endothelium-derived contracting factors in renal versus mesenteric arteries.

Cite This Study

Jameson et al. (1992) studied this question.

synapsesocial.com/papers/6a961900ec951d63bc3d4915 https://doi.org/10.1097/00005344-199204002-00053

Topics

Hypertension management

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Endothelial Dysfunction of Resistance Arteries of Spontaneously Hypertensive Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Endothelial Dysfunction of Resistance Arteries of Spontaneously Hypertensive Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider