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March 1, 1996British Journal of PharmacologyOpen Access

Modulation by nitric oxide and prostaglandin of the renal vascular response to angiotensin II (3–8)

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Population

Anaesthetized spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY)

Comparison

Intrarenal infusion of angiotensin II with or… vs Angiotensin II infusion or baseline conditions…

Design

Preclinical

Authors

MYMakoto YoshidaSapporo Medical UniversityMKMasanobu KikukawaTohoku UniversityHHHiroaki HisaKyushu University

Discussion

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Overview

NO and prostaglandins modulate AIV renal vasoconstriction in rats; leaves open human hemodynamic relevance.

Structured PICO

P
Population
Anaesthetized spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY)
I
Intervention
Intrarenal infusion of angiotensin II (3-8) (AIV) with or without L-NAME (nitric oxide synthase inhibitor), indomethacin (cyclooxygenase inhibitor), or losartan (AII receptor antagonist)
C
Comparator
Angiotensin II (AII) infusion or baseline conditions without inhibitors
O
Outcome
Renal vascular response (vasoconstriction)surrogate

Nitric oxide and prostaglandins modulate the renal vascular response to angiotensin II (3-8) in rat models.

Cite This Study

Yoshida et al. (1996) studied this question.

synapsesocial.com/papers/6a8d0ddeb78e02efa68e4e8fhttps://doi.org/10.1111/j.1476-5381.1996.tb15276.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Regional haemodynamic effects of angiotensin II (3–8) in conscious rats1993 · 55 citations
  2. 2Modulation of angiotensin II-induced vasoconstriction by endothelium-derived relaxing factor in the isolated microperfused rabbit afferent arteriole.1991 · 215 citations
  3. 3NG-monomethyl-L-arginine and nitroarginine potentiate pressor responsiveness of vasoconstrictors in conscious rats1992 · 61 citations
  4. 4Angiotensin degradation products mediate endothelium-dependent dilation of rabbit brain arterioles.1991 · 129 citations
  5. 5Nitric oxide‐mediated changes in vascular reactivity in pregnancy in spontaneously hypertensive rats1993 · 27 citations