January 1, 1998Journal of Smooth Muscle ResearchOpen Access

Involvement of Endothelium-Derived Factors in Controlling the Active Tone of Smooth Muscle in Aorta from Hypertensive Rats.

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Structured PICO

Population

Aortae from various strains of spontaneously hypertensive rats and normotensive Wistar Kyoto rats (WKY)

Intervention

Pharmacological manipulation with N(G)-nitro-L-arginine (L-NNA), L-arginine, indomethacin, apamin, charybdotoxin, and Ca-antagonists

Comparator

Endothelium-denuded preparations and normotensive WKY rat aortae

Outcome

Active tone of smooth musclesurrogate

In hypertensive rats, the active tone of aortic smooth muscle is strongly depressed by endothelium-derived nitric oxide and potentiated by cyclooxygenase pathway products.

Discussion

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Implication

Highlights NO/COX modulation of tone in hypertensive rat aortas; leaves open human translation.

Cite This Study

Sekiguchi et al. (1998) studied this question.

synapsesocial.com/papers/6a7daa5cf980e836411873f4 https://doi.org/10.1540/jsmr.34.221

Topics

Hypertension management

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Involvement of Endothelium-Derived Factors in Controlling the Active Tone of Smooth Muscle in Aorta from Hypertensive Rats.

Structured PICO

Discussion

Implication

Cite This Study

Topics

Involvement of Endothelium-Derived Factors in Controlling the Active Tone of Smooth Muscle in Aorta from Hypertensive Rats.

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider