Key result
In angiotensin II-induced hypertensive rats, adventitial superoxide anion production was up to 15-fold higher than in sham rats, mediating spontaneous aortic tone by inactivating nitric oxide.
Population
Isolated rat aorta from hypertensive rats infused with angiotensin II
Comparison
Pharmacological inhibitors and endothelium removal vs Sham-operated rats and untreated aortic rings
Design
Preclinical
Authors
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Adventitial superoxide may mediate vascular tone in experimental hypertension; hypothesis-generating for human studies and should not change practice.
The adventitia plays an active role in regulating smooth muscle tone during hypertension via superoxide anion production that inactivates endothelium-derived nitric oxide.
Wang et al. (1999) studied Angiotensin II-induced hypertension. Angiotensin II infusion vs. Sham-operated rats was evaluated on Spontaneous tone and superoxide anion production. In angiotensin II-induced hypertensive rats, adventitial superoxide anion production was up to 15-fold higher than in sham rats, mediating spontaneous aortic tone by inactivating nitric oxide.
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