What does this research mean for the field?

Angiotensin II, but not catecholamines, causes acute vascular superoxide production, which contributes to its acute pressor and vasoconstrictive effects. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To determine whether angiotensin II rapidly stimulates vascular superoxide production to mediate acute vasoconstriction and pressor responses.

February 1, 2000Journal of Hypertension

Acute production of vascular superoxide by angiotensin II but not by catecholamines

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Why the study?

Does angiotensin II acutely produce vascular superoxide that contributes to vascular contraction compared to catecholamines in rat models?

Population

Rats (in vivo) and rat aortic rings (in vitro)

Comparison

Angiotensin II with and without superoxide… vs Catecholamines (epinephrine and norepinephrine)

Design

Preclinical

Follow-up

acute

Authors

TKTakeshi KawazoeTokyo Medical and Dental University HKHiroaki KosakaToyo Engineering (Japan)HYHirohito YoneyamaSaint Martin's University

Discussion

Member takes

Implication

Hypothesis-generating for superoxide in Ang II vasoconstriction in rats; should not yet change clinical practice.

Key Points

To determine whether angiotensin II rapidly stimulates vascular superoxide production to mediate acute vasoconstriction and pressor responses.
Assessed changes in mean arterial blood pressure induced by angiotensin II in rats pretreated intravenously with or without superoxide dismutase (SOD).
Measured acute superoxide production via Cypridina luciferin analog chemiluminescence and monitored isometric tension in isolated rat aortic rings exposed to angiotensin II or catecholamines (epinephrine and norepinephrine) with or without SOD.
Intravenous SOD pretreatment significantly blunted the acute pressor effects elicited by angiotensin II in vivo.
Angiotensin II induced immediate increases in chemiluminescence and isometric tension in rat aortic rings, both of which were significantly reduced by SOD.
Epinephrine and norepinephrine showed no significant superoxide production or modulation by SOD.

Structured PICO

Does angiotensin II acutely produce vascular superoxide that contributes to vascular contraction compared to catecholamines in rat models?

Population

Rats (in vivo) and rat aortic rings (in vitro)

Intervention

Angiotensin II with and without superoxide dismutase (SOD) pretreatment

Comparator

Catecholamines (epinephrine and norepinephrine)

Outcome

Mean arterial blood pressure, vascular superoxide production (chemiluminescence), and isometric tensionsurrogate

Angiotensin II, but not catecholamines, causes acute vascular superoxide production which contributes to its acute pressor effects.

Cite This Study

Kawazoe et al. (2000) studied this question.

synapsesocial.com/papers/6a1d756933e2df9c962f8d64 https://doi.org/10.1097/00004872-200018020-00008

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Acute production of vascular superoxide by angiotensin II but not by catecholamines

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Acute production of vascular superoxide by angiotensin II but not by catecholamines

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider