Key result
DOCA-salt induced low-renin hypertension in rats significantly increased aortic superoxide production (3972 vs 852, P<0.05) and impaired endothelium-dependent vascular relaxation.
Why the study?
Does increased vascular superoxide production modulate blood pressure and vascular function in low-renin hypertension induced by DOCA-salt in rats?
Population
Rats treated with deoxycorticosterone acetate and saline drinking water for 3 weeks to induce low-renin…
Comparison
Heparin-binding superoxide dismutase or Losartan vs Control rats
Design
Preclinical
Follow-up
3 weeks
Authors
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Should not change clinical practice in hypertension; hypothesis-generating for superoxide's role in endothelial dysfunction in low-renin models.
Does increased vascular superoxide production modulate blood pressure and vascular function in low-renin hypertension induced by DOCA-salt in rats?
Absolute Event Rate: 3972% vs 852%
p-value: p=<0.05
Increased vascular superoxide production impairs endothelium-dependent vascular relaxation but does not modulate blood pressure in low-renin hypertension.
Somers et al. (2000) studied Low-renin hypertension. DOCA and saline drinking water vs. Controls was evaluated on Aortic superoxide production (p=<0.05). DOCA-salt induced low-renin hypertension in rats significantly increased aortic superoxide production (3972 vs 852, P<0.05) and impaired endothelium-dependent vascular relaxation.
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