Population
Male Sprague-Dawley rats with desoxycorticosterone acetate-salt hypertension and sham-operated normotensive…
Comparison
Endothelin subtype A receptor blockade with… vs Normotensive sham-operated rats
Design
Preclinical
Follow-up
3 to 4 weeks
Authors
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Supports venous tone mediation by ETA and sympathetic pathways in hypertensive rats; leaves open human translation.
In DOCA-salt hypertensive rats, increased venous smooth muscle tone is mediated independently by endogenous endothelin-1 acting on ETA receptors and sympathetic venoconstrictor activity.
Fink et al. (2000) studied this question.
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