Why the study?
Does ET(B) receptor antagonism with A-192621 increase arterial pressure and alter renal function in DOCA-salt hypertensive rats?
Population
Male Sprague-Dawley rats undergoing uninephrectomy and treated with either DOCA and salt or placebo.
Comparison
A-192621 (ET-selective antagonist) 10 mg/kg/day… vs Untreated DOCA-salt rats and placebo rats.
Design
Preclinical
Follow-up
1 week
Authors
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ET(B) antagonism elevates pressure in DOCA-salt rats; supports compensatory renal role but leaves human implications open.
Does ET(B) receptor antagonism with A-192621 increase arterial pressure and alter renal function in DOCA-salt hypertensive rats?
ET(B) receptors in the renal medulla are upregulated in DOCA-salt hypertensive rats and may serve a compensatory role to maintain lower arterial pressure by promoting salt and water excretion.
Pollock et al. (2000) studied this question.
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