What is the clinical evidence from this study?

Study design: Other. Population: DOCA-salt-induced hypertension. Intervention: ET(B) receptor deficiency vs. Wild-type (+/+) rats. Primary outcome: Systolic blood pressure, renal dysfunction, and vascular hypertrophy.

November 28, 2000CirculationOpen Access

Exaggerated Vascular and Renal Pathology in Endothelin-B Receptor–Deficient Rats With Deoxycorticosterone Acetate–Salt Hypertension

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Key result

ET(B) receptor-deficient rats exhibited earlier and higher increases in systolic blood pressure and more severe renal and vascular damage in response to DOCA-salt than wild-type rats.

Why the study?

Does ABT-627 reduce DOCA-salt-induced hypertension and tissue injury in ET(B) receptor-deficient rats?

Population

Transgenic spotting-lethal rats with ET receptor deficiency (rescued with DssH-ET transgene) and wild-type…

Comparison

ABT-627 (ET receptor antagonist) chronic treatment vs Wild-type rats and/or no ABT-627 treatment

Design

Preclinical

Authors

YMYasuo MatsumuraAmerican Pharmacists Association TKToshihiko KuroOsaka University of Pharmaceutical Sciences YKYutaka KobayashiJapanese Red Cross Society Kyoto Daini Hospital

Discussion

Member takes

Implication

ET(B) receptor protection against salt-induced hypertension is reinforced in this rat model; leaves open translation to human disease.

Structured PICO

Does ABT-627 reduce DOCA-salt-induced hypertension and tissue injury in ET(B) receptor-deficient rats?

Population

Homozygous (sl/sl) and wild-type (+/+) rats with DssH-ET(B) transgene expression treated with DOCA-salt.

Exposure

ABT-627 (ET(A) receptor antagonist) chronic treatment

Comparator

Wild-type rats and/or no ABT-627 treatment

Outcome

Systolic blood pressure, renal dysfunction, histological damage, vascular hypertrophy, and ET-1 levelssurrogate

ET(B) receptors play a protective role in DOCA-salt-induced hypertension, and ET(A) receptor antagonism with ABT-627 prevents hypertension and tissue injury in this model.

Cite This Study

Matsumura et al. (2000) studied DOCA-salt-induced hypertension. ET(B) receptor deficiency vs. Wild-type (+/+) rats was evaluated on Systolic blood pressure, renal dysfunction, and vascular hypertrophy. ET(B) receptor-deficient rats exhibited earlier and higher increases in systolic blood pressure and more severe renal and vascular damage in response to DOCA-salt than wild-type rats.

synapsesocial.com/papers/6a20d8678446b104fdecb499 https://doi.org/10.1161/01.cir.102.22.2765

Topics

Hypertension management

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Exaggerated Vascular and Renal Pathology in Endothelin-B Receptor–Deficient Rats With Deoxycorticosterone Acetate–Salt Hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Exaggerated Vascular and Renal Pathology in Endothelin-B Receptor–Deficient Rats With Deoxycorticosterone Acetate–Salt Hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

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