Why the study?
Does ETA receptor blockade with A-127722 reduce blood pressure and improve renal function in DOCA-salt hypertensive rats?
Population
Rats with right nephrectomy and DOCA-salt induced hypertension
Comparison
ETA receptor antagonist A-127722 administered in… vs DOCA-salt rats without A-127722, and…
Design
Preclinical
Follow-up
3 weeks
Authors
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Hypothesis-generating for ETA blockade in salt-sensitive hypertension; prospective human studies needed before clinical consideration.
Does ETA receptor blockade with A-127722 reduce blood pressure and improve renal function in DOCA-salt hypertensive rats?
ETA receptor blockade attenuates hypertension but does not prevent renal dysfunction in the DOCA-salt rat model.
Allcock et al. (1998) studied this question.
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