Why the study?
Does endothelin-A receptor antagonism with A-127722 reduce hypertension and renal injury in Dahl salt-sensitive rats on a high salt diet?
Population
Dahl salt-sensitive rats and Dahl salt-resistant rats placed on a high sodium diet for 3 weeks.
Comparison
Chronic selective ET antagonist treatment at a… vs Untreated control group of DS and DR rats on the…
Design
Preclinical
Follow-up
3 weeks
Authors
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Hypothesis-generating for ET-A antagonism in salt-sensitive hypertension; human trials needed before clinical adoption.
Does endothelin-A receptor antagonism with A-127722 reduce hypertension and renal injury in Dahl salt-sensitive rats on a high salt diet?
Endothelin-A receptor antagonism attenuates salt-induced hypertension and renal injury in a Dahl salt-sensitive rat model, suggesting a role for ET(A) receptors in salt-sensitive hypertension.
Kassab et al. (1998) studied this question.
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