Why the study?
Does J-104132 reduce blood pressure in Dahl salt-sensitive rats?
Does J-104132 reduce blood pressure in Dahl salt-sensitive rats?
Endothelin-1 plays a pathophysiological role in salt-sensitive hypertension, and mixed ET(A)/ET(B) receptor antagonists can effectively reduce blood pressure in this preclinical model.
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Supports mixed ET antagonism in salt-sensitive hypertension models; leaves open clinical translation.
Ikeda et al. (1999) studied this question.
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