Population
Dahl rats, including isolated vascular smooth muscle cells, glomerular mesangial cells, deendothelialized…
Comparison
Exposure to endothelin-1 and ouabain vs Dahl-R rats compared to Dahl-S rats
Design
Preclinical
Authors
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Supports endothelin involvement in salt-sensitive hypertension pathogenesis; hypothesis-generating in animal models, leaves open human relevance.
Increased responsiveness to ET-1 and inducibility of ir-ET production in prehypertensive Dahl-S rats suggest endothelin plays a role in the pathogenesis of salt-sensitive hypertension, potentially triggered by ouabain-like factors.
Goligorsky et al. (1991) studied this question.
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