September 1, 1997Hypertension
Role of Endothelin in Mediating the Attenuated Renal Hemodynamics in Dahl Salt-Sensitive Hypertension
Why the study?
Does endothelin antagonism improve renal hemodynamics and reduce arterial pressure in Dahl salt-sensitive rats on a high sodium diet?
Population
Conscious, chronically instrumented Dahl salt-sensitive and Dahl salt-resistant rats fed a high sodium diet…
Comparison
Nonspecific ET-ET antagonist SB 209670… vs Dahl salt-resistant rats receiving the same…
Design
Preclinical
Follow-up
60 to 75 minutes
Authors
Discussion
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Implication
Should not yet change hypertension practice; hypothesis-generating for endothelin antagonism in salt-sensitive models.
Structured PICO
Does endothelin antagonism improve renal hemodynamics and reduce arterial pressure in Dahl salt-sensitive rats on a high sodium diet?
P
Population
Conscious, chronically instrumented Dahl salt-sensitive (DS) and Dahl salt-resistant (DR) rats fed a high sodium (8%) diet for 3 weeks.
I
Intervention
Nonspecific ET(A)-ET(B) antagonist SB 209670 administered either via intravenous infusion (30 microg/kg/min for 75 minutes) or renal interstitial infusion (200 ng/kg/min for 60 minutes).
C
Comparator
Dahl salt-resistant (DR) rats receiving the same intervention, as well as baseline measurements prior to infusion.
O
Outcome
Arterial pressure and renal function (glomerular filtration rate, renal plasma flow, renal vascular resistance).surrogate
Endothelin antagonism improves renal hemodynamics and lowers arterial pressure in Dahl salt-sensitive rats, suggesting that endothelin plays a key role in mediating salt-sensitive hypertension.
Cite This Study
Kassab et al. (1997) studied this question.