Key result
In a rat model of mild DOCA-salt hypertension, global sympathetic nervous system activity was not increased, and fully intact renal nerves were not essential for hypertension development.
Why the study?
Does DOCA-salt administration increase global sympathetic nervous system activity or require intact renal nerves for hypertension development in male Sprague-Dawley rats?
Population
Chronically catheterized male Sprague-Dawley rats drinking water containing 1% NaCl and 0.2% KCl
Comparison
Subcutaneous DOCA pellet implantation, with or… vs Sham implantation, with or without sham…
Design
Preclinical
Follow-up
14 days
Authors
Loading...
Questions sympathetic or renal nerve targeting in mild DOCA-salt hypertension; leaves open non-neural mechanisms for further animal and human study.
Does DOCA-salt administration increase global sympathetic nervous system activity or require intact renal nerves for hypertension development in male Sprague-Dawley rats?
Absolute Event Rate: 128% vs 109%
p-value: p=<0.05
Global sympathetic nervous system activity is not increased, and fully intact renal nerves are not essential for the development of mild DOCA-salt hypertension in rats.
Kandlikar et al. (2011) studied Mild DOCA-salt hypertension. DOCA and high salt intake vs. Sham implantation was evaluated on Mean arterial pressure (MAP) at day 14 (p=<0.05). In a rat model of mild DOCA-salt hypertension, global sympathetic nervous system activity was not increased, and fully intact renal nerves were not essential for hypertension development.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: