Key result
Splanchnic denervation by celiac ganglionectomy significantly attenuated the increase in blood pressure compared to sham surgery in rats with mild DOCA-salt hypertension (15.6 vs 25.6 mmHg).
Why the study?
Does splanchnic denervation via celiac ganglionectomy prevent the development of mild DOCA-salt hypertension in rats?
Does splanchnic denervation via celiac ganglionectomy prevent the development of mild DOCA-salt hypertension in rats?
Absolute Event Rate: 15.6% vs 25.6%
p-value: p=<0.05
Intact splanchnic innervation is necessary for the development of mild DOCA-salt hypertension, likely due to increased splanchnic vascular reactivity rather than increased sympathetic nerve activity.
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Attenuates BP rise in this rat model; leaves open whether splanchnic denervation merits human trials in salt-sensitive hypertension.
Kandlikar et al. (2011) studied Mild DOCA-salt hypertension. Celiac ganglionectomy (CGX) vs. Sham surgery (SHAM-GX) was evaluated on Increase in blood pressure (mmHg) 28 days after DOCA treatment (p=<0.05). Splanchnic denervation by celiac ganglionectomy significantly attenuated the increase in blood pressure compared to sham surgery in rats with mild DOCA-salt hypertension (15.6 vs 25.6 mmHg).
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