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January 1, 1978Clinical and Experimental Hypertension

Differential Development of Renal, Doca-salt, and Spontaneous Hypertension in the Rat After Neonatal Sympathectomy

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Why the study?

Does neonatal sympathectomy affect the development of hypertension in different rat models?

Population

Rats in three different hypertension models: two-kidney Goldblatt renal hypertension…

Comparison

Neonatal sympathectomy by subcutaneous injection… vs Control rats with intact sympathetic nervous…

Design

Preclinical

Follow-up

Up to 12 months of age

Authors

APAbraham P. ProvoostWJWybren de Jong

Discussion

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Overview

Model-specific sympathectomy effects in rat hypertension models; hypothesis-generating for sympathetic roles but leaves open human translation.

Structured PICO

Does neonatal sympathectomy affect the development of hypertension in different rat models?

P
Population
Rats in three different hypertension models: two-kidney Goldblatt renal hypertension, deoxycorticosterone (DOCA)-salt hypertension, and spontaneous hypertensive rats (SHR)
I
Intervention
Neonatal sympathectomy by subcutaneous injection of 6-hydroxydopamine HCl
C
Comparator
Control rats with intact sympathetic nervous systems
O
Outcome
Development and level of blood pressure measured directly in conscious animals via the iliac arterysurrogate

An intact sympathetic nervous system is essential for the development of hypertension in spontaneous hypertensive rats, but protects against a rapid rise in blood pressure in DOCA-salt hypertension.

Cite This Study

Provoost et al. (1978) studied this question.

synapsesocial.com/papers/6a8af180c12eaf65c8b1f06dhttps://doi.org/10.3109/10641967809068603
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Effects of “Immunosympathectomy” on Blood Pressure and Vascular “Reactivity” in Normal and Spontaneously Hypertensive Rats1972 · 73 citations
  2. 2Reflex regulation of sympathetic activity in the spontaneously hypertensive rat.1977 · 122 citations
  3. 3Development of a Strain of Spontaneously Hypertensive Rats1963 · 2,558 citations
  4. 4A comparison of the effects of 6-hydroxy-dopamine immunosympathectomy and reserpine on the cardiovascular reactivity in the rat1970 · 33 citations
  5. 5An assessment of the role of the sympathetic nervous system in experimental hypertension using normal and immunosympathectomized rats1970 · 58 citations