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January 1, 1995Clinical and Experimental Hypertension

The Pathophysiological Role of Renal Dopamine and Kallikrein in Deoxycorticosterone Acetate (DOCA)-Salt Treated Rats

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Population

5 week-old Sprague-Dawley rats (n=17)

Comparison

Deoxycorticosterone acetate 100mg pellet, s.c… vs Vehicle and 1% saline ingestion for 4 weeks

Design

Preclinical

Follow-up

4 weeks

Authors

TIToshiya IshiguroSapporo Medical UniversityKSKazuaki ShimamotoPreventive CardiologyNUNobuyuki UraSapporo National Hospital

Discussion

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Implication

Animal data on renal dopamine and kallikrein in hypertension remain hypothesis-generating; leaves open their therapeutic relevance in human volume-dependent hypertension.

Structured PICO

P
Population
5 week-old Sprague-Dawley rats (n=17)
I
Intervention
Deoxycorticosterone acetate (DOCA) 100mg pellet, s.c., and 1% saline ingestion for 4 weeks
C
Comparator
Vehicle and 1% saline ingestion for 4 weeks
O
Outcome
Urinary excretions of free dopamine (UDA), kallikrein (UKAL), and systolic blood pressure (SBP)surrogate

In a rat model of volume-dependent hypertension, early augmentation of renal dopaminergic activity is blunted over time, while the kallikrein-kinin system may act as a compensatory response to sodium and volume retention.

Cite This Study

Ishiguro et al. (1995) studied this question.

synapsesocial.com/papers/6a7798147d04941475ae5bcfhttps://doi.org/10.3109/10641969509037409

Topics

Hypertension management
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Relationship between the Adrenergic Nervous System and Renin during Adaptation to Upright Posture: A Possible Role for 3,4-Dihydroxyphenethylamine (Dopamine)1972 · 104 citations
  2. 2Attenuated Renal Production of Dopamine in Patients with Low Renin Essential Hypertension1989 · 19 citations
  3. 3Abnormal adrenal catecholamine synthesis in salt-sensitive Dahl rats.1987 · 27 citations
  4. 4Hormonal Pattern During Development of Hypertension in Spontaneously Hypertensive Rats (SHR)1982 · 23 citations