Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
November 1, 1983AJP Regulatory Integrative and Comparative Physiology

Arterial pressure-urinary output relationship in DOCA-saline hypertensive rats

View Full Paper
Ask AI
Bookmark
Share

Population

Unanesthetized, unrestrained uninephrectomized control, normal Wistar-Imamichi rats, and DOCA-saline…

Comparison

Deoxycorticosterone acetate-saline hypertension… vs 1-K control rats and normal W-I rats

Design

Preclinical

Authors

TSTakuro SugaiNiigata UniversityYNYasushi NakagawaUniversity of MinnesotaKTK. TakedaSophia University

Discussion

Loading...

Member takes

Implication

Renal mechanisms warrant further mechanistic study in hypertension models; should not yet influence clinical practice.

Structured PICO

P
Population
Unanesthetized, unrestrained uninephrectomized (1-K) control, normal Wistar-Imamichi (W-I) rats, and DOCA-saline hypertensive rats
I
Intervention
Deoxycorticosterone acetate (DOCA)-saline hypertension induction and hydralazine administration
C
Comparator
1-K control rats and normal W-I rats
O
Outcome
Arterial pressure-urinary output (AP-UO) relationshipsurrogate

The parallel shift of the arterial pressure-urinary output relationship in DOCA-saline hypertensive rats, which is reversed by hydralazine, suggests that renal artery constriction causes the rise in arterial pressure in this model.

Cite This Study

Sugai et al. (1983) studied this question.

synapsesocial.com/papers/6a908c59ccd91641af4ddfe4https://doi.org/10.1152/ajpregu.1983.245.5.r633

Topics

Hypertension management
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Renal impairment in deoxycorticosterone acetate‐salt hypertensive rats2000 · 6 citations
  2. 2The Pathophysiological Role of Renal Dopamine and Kallikrein in Deoxycorticosterone Acetate (DOCA)-Salt Treated Rats1995 · 3 citations
  3. 3Cortical and medullary hemodynamics in deoxycorticosterone acetate-salt hypertensive mice.1998 · 36 citations
  4. 4Mild DOCA-salt hypertension: sympathetic system and role of renal nerves2011 · 42 citations
  5. 5Decreased density of vascular receptors for atrial natriuretic peptide in DOCA-salt hypertensive rats.1987 · 46 citations