Key result
Compared with controls, DOCA-NaCl increased mean arterial blood pressure, whereas DOCA-NaHCO3 and DOCA-KHCO3 did not, suggesting intracellular chloride or sodium accumulation drives hypertension.
Population
42 male rats
Comparison
Deoxycorticosterone acetate treatment combined… vs Untreated control rats and rats receiving 1%…
Design
Preclinical
Follow-up
3 weeks
Authors
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In a DOCA rat model, NaCl but not NaHCO3 or KHCO3 increased blood pressure, suggesting that intracellular Cl- or Na+ accumulation drives salt-sensitive hypertension rather than simple volume expansion.
In a DOCA rat model, NaCl but not NaHCO3 or KHCO3 increased blood pressure, suggesting that intracellular Cl- or Na+ accumulation drives salt-sensitive hypertension rather than simple volume expansion.
Ziomber et al. (2008) studied Salt-sensitive hypertension (n=42). DOCA-NaCl, DOCA-NaHCO3, or DOCA-KHCO3 vs. Untreated control or 1% NaCl alone was evaluated on Mean arterial blood pressure (MAP) and tissue electrolyte and water content. Compared with controls, DOCA-NaCl increased mean arterial blood pressure, whereas DOCA-NaHCO3 and DOCA-KHCO3 did not, suggesting intracellular chloride or sodium accumulation drives hypertension.
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