Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 9, 1999Circulation ResearchOpen Access

Modulation of Extracellular Superoxide Dismutase Expression by Angiotensin II and Hypertension

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does angiotensin II modulate extracellular superoxide dismutase expression in vascular tissue?

Population

Mice, mouse aortas in organoid culture, and human aortic smooth muscle cells

Comparison

Angiotensin II infusion vs Control, norepinephrine-induced hypertension…

Design

Preclinical

Follow-up

7 days (in vivo)

Authors

TFTohru FukaiAugusta UniversityMSMartin R. SiegfriedEmory UniversityMUMasuko Ushio‐FukaiVascular / Pulmonary Vascular

Discussion

Loading...

Member takes

Implication

May inform RAS effects on vascular antioxidants; leaves open clinical translation from experimental models.

Structured PICO

Does angiotensin II modulate extracellular superoxide dismutase expression in vascular tissue?

P
Population
Mice, mouse aortas in organoid culture, and human aortic smooth muscle cells
I
Intervention
Angiotensin II infusion (1.1 mg/kg for 7 days in vivo; 100 nmol/L in vitro)
C
Comparator
Control, norepinephrine-induced hypertension (5.6 mg/kg/d), and co-administration with losartan or PD985059
O
Outcome
Expression of extracellular superoxide dismutase (ecSOD) protein and mRNAsurrogate

Cite This Study

Fukai et al. (1999) studied this question.

synapsesocial.com/papers/6a0fc281e6385ae0c9fcaefchttps://doi.org/10.1161/01.res.85.1.23

Topics

Hypertension management
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of Superoxide in Angiotensin II–Induced but Not Catecholamine-Induced Hypertension1997 · 828 citations
  2. 2Angiotensin II regulates parathyroid hormone-related protein expression in cultured rat aortic smooth muscle cells through transcriptional and post-transcriptional mechanisms.1993 · 130 citations
  3. 3NADH oxidoreductase is a major source of superoxide anion in bovine coronary artery endothelium1994 · 538 citations
  4. 4A Noninvasive Computerized Tail-Cuff System for Measuring Blood Pressure in Mice1995 · 595 citations
  5. 5Angiotensin II induces c-fos expression in smooth muscle via transcriptional control.1989 · 202 citations