May 1, 1992Hypertension
Nitric oxide inactivates endothelium-derived contracting factor in the rat aorta.
Population
Thoracic aortas of normotensive and spontaneously hypertensive rats, with and without endothelium
Comparison
Acetylcholine in the presence of inhibitors of… vs Untreated rings (acetylcholine alone)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Should not change hypertension management; leaves open mechanistic translation from rat models.
Structured PICO
P
Population
Thoracic aortas of normotensive and spontaneously hypertensive rats, with and without endothelium
I
Intervention
Acetylcholine in the presence of inhibitors of endothelium-dependent relaxations (oxyhemoglobin, NG-monomethyl L-arginine, methylene blue, superoxide dismutase, deferoxamine, indomethacin)
C
Comparator
Untreated rings (acetylcholine alone)
O
Outcome
Isometric tension (contractions to acetylcholine)surrogate
Endothelium-derived relaxing factor (nitric oxide) appears to inhibit endothelium-dependent contractions to acetylcholine in spontaneously hypertensive rat aortas by chemically inactivating the contracting factor.
Cite This Study
Auch–Schwelk et al. (1992) studied this question.