November 1, 1992AJP Lung Cellular and Molecular Physiology

Methylene blue inhibits neurogenic cholinergic vasodilator responses in the pulmonary vascular bed of the cat

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Population

Intact-chest cats pretreated with reserpine or phenoxybenzamine

Comparison

Methylene blue (intralobar infusion) vs Baseline responses or responses to…

Design

Preclinical

Authors

TMT. McMahonDurham VA Health Care System PKPhilip J. KadowitzMarquette University

Discussion

Member takes

Implication

Should not change methylene blue use in patients; leaves open guanylate cyclase role in human pulmonary cholinergic vasodilation.

Structured PICO

Population

Intact-chest cats pretreated with reserpine or phenoxybenzamine

Intervention

Methylene blue (intralobar infusion)

Comparator

Baseline responses or responses to non-endothelium-dependent vasodilators

Outcome

Pulmonary vasodilator responses (lobar arterial pressure and pulmonary lobar vascular resistance) to efferent vagal stimulationsurrogate

Methylene blue inhibits neurogenic cholinergic vasodilation in the feline pulmonary vascular bed, supporting the role of guanylate cyclase in this pathway.

Cite This Study

McMahon et al. (1992) studied this question.

synapsesocial.com/papers/6a8735cec7caab105a155bfb https://doi.org/10.1152/ajplung.1992.263.5.l575

View Full Paper

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Methylene blue inhibits neurogenic cholinergic vasodilator responses in the pulmonary vascular bed of the cat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Methylene blue inhibits neurogenic cholinergic vasodilator responses in the pulmonary vascular bed of the cat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider