Key result
Intravenous infusion of epinephrine had no effect on pulmonary vascular resistance in intact cats, but increased it after removal of sympathetic ganglia, whereas norepinephrine increased it.
This preclinical study demonstrates that pulmonary vascular resistance in cats is modulated by sympathetic innervation and responds differently to epinephrine depending on the presence of intact sympathetic ganglia.
Highlights sympathetic modulation of pulmonary responses to catecholamines; leaves open relevance to human pulmonary vascular disease.
Constant intravenous infusion of epinephrine has no effect on the pulmonary vascular resistance (P.V.R.) of the cat under chloralose anesthesia, either when the chest is opened and artificial ventilation is used, or when the animal is respiring naturally. The same dose of epinephrine given after removal of the stellate ganglia and upper 4 to 5 thoracic sympathetic ganglia, can cause an increase of P.V.R. Removal of such ganglia causes a decrease of P.V.R. Electrical stimulation of the cardiac branches from both stellate ganglia causes either an increase or a decrease of P.V.R. Increases of P.V.R. have been produced by intravenous infusion of norepinephrine.
No takes yet. Share an insight, caveat, or question.
Duke et al. (1960) studied this question. Epinephrine and norepinephrine was evaluated on Pulmonary vascular resistance (P.V.R.). Intravenous infusion of epinephrine had no effect on pulmonary vascular resistance in intact cats, but increased it after removal of sympathetic ganglia, whereas norepinephrine increased it.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: