Why the study?
What is the effect of intracoronary epinephrine and norepinephrine on coronary vascular resistance in a dog heart model?
Population
Beating and fibrillating dog heart model (heart performed no external work, coronary blood flow held constant)
Design
Preclinical
Authors
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These canine observations should not change practice; leaves open dose-dependent coronary effects for human investigation.
What is the effect of intracoronary epinephrine and norepinephrine on coronary vascular resistance in a dog heart model?
In a dog heart model, epinephrine and norepinephrine demonstrate dose-dependent effects on coronary vascular resistance, causing direct vasoconstriction at low concentrations and indirect vasodilation at high concentrations.
Hardin et al. (1961) studied this question.
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