Why the study?
Does continuously infused intravenous l-epinephrine and l-norepinephrine alter total coronary flow and myocardial oxygen consumption in open-chested anesthetized dogs?
Population
Open-chested anesthetized dogs prepared for measurement of total coronary flow and myocardial oxygen…
Design
Preclinical
Authors
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These canine data should not inform catecholamine dosing in patients; leaves open translation of efficiency changes to human myocardium.
Does continuously infused intravenous l-epinephrine and l-norepinephrine alter total coronary flow and myocardial oxygen consumption in open-chested anesthetized dogs?
Intravenous infusion of catecholamines directly alters coronary vessel physiology, increasing myocardial oxygen consumption and decreasing mechanical efficiency in a canine model.
Gerola et al. (1959) studied this question.
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