Key result
Different catecholamines produce distinct linear relationships between cardiac output and oxygen consumption in awake dogs.
Why the study?
Do different catecholamines have distinct relationships between cardiac output and oxygen consumption in healthy dogs?
Population
10 trained, healthy dogs in the basal metabolic state with chronically implanted ultrasonic flow transducers…
Comparison
Increasing doses of norepinephrine, epinephrine… vs Baseline conditions and comparison among the…
Design
Preclinical, randomly varied sequence
Authors
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Caution against extrapolating healthy-dog findings to patients; leaves open whether synthetic agents confer metabolic advantages in human critical illness.
RCT (n=10)
randomly varied sequence
Do different catecholamines have distinct relationships between cardiac output and oxygen consumption in healthy dogs?
p-value: p=< .05
Synthetic catecholamines like dobutamine and dopexamine increase cardiac output with fewer metabolic effects (less increase in oxygen consumption) compared to endogenous catecholamines like norepinephrine.
Scheeren et al. (2000) conducted an RCT in healthy dogs (n=10). Catecholamines (norepinephrine, epinephrine, dobutamine, dopexamine) vs. baseline conditions was evaluated on Relationships between cardiac output (Q) and oxygen consumption (VO2) (p=< .05). Infusion of different catecholamines in awake dogs produced linear relationships between cardiac output and oxygen consumption with significantly different slopes between agents (p < .05).