Why the study?
Do epinephrine and norepinephrine have opposing effects on coronary thrombosis in an anesthetized canine model?
Population
Anesthetized canine model of coronary thrombosis (n = 25)
Comparison
Infusion of epinephrine, norepinephrine, or a… vs Control periods (baseline)
Design
Preclinical
Follow-up
40 minutes per experimental period
Authors
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Opposing catecholamine effects on canine coronary thrombosis; hypothesis-generating and should not yet inform human ACS management.
Do epinephrine and norepinephrine have opposing effects on coronary thrombosis in an anesthetized canine model?
Epinephrine stimulates while norepinephrine inhibits coronary artery thrombosis in a canine model, demonstrating opposing effects of these major circulating catecholamines.
Lin et al. (1995) studied this question.
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