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Studies on the intracoronary administration of epinephrine and norepinephrine in the beating, fibrillating or potassium-arrested dog heart indicate that the primary action of these compounds on the coronary vessels is vasoconstriction. The vasodilation observed with epinephrine and norepinephrine is probably secondary to the increased rate of myocardial metabolism induced by these drugs.
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Circulation Research
Case Western Reserve University
University School
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Robert M. Berne (Mon,) studied this question.