Why the study?
Does intracoronary administration of epinephrine and norepinephrine cause vasoconstriction or vasodilation in the dog heart?
Population
beating, fibrillating or potassium-arrested dog heart
Design
Preclinical
Authors
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Informs experimental coronary models; leaves open translation to human physiology and practice.
Does intracoronary administration of epinephrine and norepinephrine cause vasoconstriction or vasodilation in the dog heart?
In a canine model, the primary direct effect of intracoronary epinephrine and norepinephrine is coronary vasoconstriction, while observed vasodilation is a secondary metabolic effect.
Robert M. Berne (1958) studied this question.
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