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January 1, 1994Circulation

Interaction between plasma potassium and epinephrine in coronary thrombosis in dogs.

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Why the study?

Does raising plasma potassium inhibit coronary thrombosis and block the potentiating effect of epinephrine in a canine model?

Population

Canine model of coronary thrombosis

Comparison

Acutely raising plasma potassium to… vs Baseline state or epinephrine infusion alone

Design

Preclinical

Follow-up

40 minutes

Authors

HLHong LinNinghai First Hospital Medicare and Health GroupDYDavid B. YoungIndiana University Bloomington

Discussion

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Overview

May inhibit experimental coronary thrombosis; hypothesis-generating for human studies and should not change practice.

Structured PICO

Does raising plasma potassium inhibit coronary thrombosis and block the potentiating effect of epinephrine in a canine model?

P
Population
Canine model of coronary thrombosis
I
Intervention
Acutely raising plasma potassium to approximately 6.0 mEq/L, with or without epinephrine infusion (0.5 microgram.kg-1 x min-1)
C
Comparator
Baseline state or epinephrine infusion alone
O
Outcome
Frequency of cyclic blood flow reductions (CFRs) resulting from thrombus formation in the circumflex arterysurrogate

Acutely raising plasma potassium inhibits coronary thrombosis and blocks the pro-thrombotic effects of epinephrine in a canine model, suggesting a protective role of potassium against thrombosis.

Cite This Study

Lin et al. (1994) studied this question.

synapsesocial.com/papers/6a8a6db0186271ac9933639fhttps://doi.org/10.1161/01.cir.89.1.331
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Also Consider

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