Why the study?
Does intracoronary bradykinin infusion reduce the severity of ischaemia-induced arrhythmias in anaesthetized dogs?
Population
Dogs anaesthetized with chloralose and urethane undergoing coronary artery occlusion
Comparison
Bradykinin 25 ng kg-1 min-1 infused into a small… vs Saline infusion
Design
Preclinical
Follow-up
35 minutes (10 min prior to and 25 min during occlusion)
Authors
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Bradykinin attenuates ischemia-induced arrhythmias in dogs; hypothesis-generating for cardioprotection, requiring human trials before any clinical consideration.
Does intracoronary bradykinin infusion reduce the severity of ischaemia-induced arrhythmias in anaesthetized dogs?
Intracoronary bradykinin profoundly reduces ischaemia-induced arrhythmias in a canine model, suggesting it acts as an endogenous myocardial protective substance during preconditioning.
Végh et al. (1991) studied this question.
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