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April 1, 1991Journal of Cardiovascular Pharmacology

In Vivo Effect of Bradykinin During Ischemia and Reperfusion

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Why the study?

Does bradykinin infusion during ischemia and reperfusion improve electrical stability in a pig model of acute myocardial infarction?

Population

21 pigs with acute myocardial infarction induced by transluminal occlusion of the left coronary artery for…

Comparison

Bradykinin administered by a 30-min infusion… vs Saline infusion

Design

Preclinical

Follow-up

2 weeks

Authors

TTT TobeDiakonessenhuis hospitalCLCees D. J. de LangenUniversity of GroningenRTRené A. TioCardiac Imaging

Discussion

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Implication

No immediate clinical implications; hypothesis-generating for bradykinin in human ischemia-reperfusion injury.

Key Points

  • This study assesses the impact of bradykinin on electrical stability after ischemia and reperfusion following myocardial infarction.
  • Induced acute myocardial infarction in 21 pigs via left coronary artery occlusion for 45 minutes
  • Administered bradykinin or saline infusion during ischemia and reperfusion
  • Analyzed creatine kinase levels, QRS duration, heart refractory periods, and inducibility of ventricular tachycardia.
  • Creatine kinase levels were significantly lower in bradykinin-treated pigs (p<0.001)
  • Filtered QRS duration was prolonged in saline-treated pigs compared to bradykinin-treated pigs (p<0.05)
  • Longer refractory periods in saline-treated hearts (106% vs. 95%, p<0.05) and greater variance in current thresholds (p<0.001).

Structured PICO

Does bradykinin infusion during ischemia and reperfusion improve electrical stability in a pig model of acute myocardial infarction?

P
Population
21 pigs with acute myocardial infarction induced by transluminal occlusion of the left coronary artery for 45 min
I
Intervention
Bradykinin administered by a 30-min infusion starting after 30 min of coronary occlusion and continued until 15 min after reperfusion
C
Comparator
Saline infusion
O
Outcome
Electrical stability 2 weeks after myocardial infarction (assessed by filtered QRS duration, terminal voltage of QRS, refractory periods, current thresholds, and inducibility of sustained ventricular tachycardia)surrogate

In a porcine model of myocardial infarction, bradykinin infusion during ischemia and reperfusion improved long-term electrical stability and reduced infarct size markers without affecting overall survival.

Cite This Study

Tobe et al. (1991) studied this question.

synapsesocial.com/papers/6a1feaec2065d284090da3fchttps://doi.org/10.1097/00005344-199104000-00012
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of Bradykinin on Inducible Sustained Ventricular Tachycardia Two Weeks After Myocardial Infarction in Pigs1991 · 7 citations
  2. 2Local intracoronary infusions of bradykinin profoundly reduce the severity of ischaemia‐induced arrhythmias in anaesthetized dogs1991 · 106 citations
  3. 3Intracoronary infusion of bradykinin: effects on noradrenaline overflow following reperfusion of ischemic myocardium in the anesthetized dog1994 · 11 citations
  4. 4Bradykinin improves postischaemic recovery in the rat heart: role of high energy phosphates, nitric oxide, and prostacyclin1995 · 28 citations
  5. 5Bradykinin elicits “second window” myocardial protection in rat heart through an NO-dependent mechanism2001 · 34 citations