Why the study?
Does bradykinin pretreatment improve postischaemic functional recovery in isolated rat hearts?
Population
Isolated, buffer-perfused rat hearts subjected to 30 min of global ischaemia followed by 30 min of reperfusion
Comparison
0.1 microM bradykinin for 10 min before… vs Control group (no pretreatment)
Design
Preclinical
Follow-up
30 minutes of reperfusion
Authors
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Bradykinin may mimic preconditioning-like protection in isolated rat hearts; hypothesis-generating for B2-agonism with no clinical implications yet.
Does bradykinin pretreatment improve postischaemic functional recovery in isolated rat hearts?
Bradykinin protects against postischaemic contractile dysfunction via B2-receptors to a similar extent as ischaemic preconditioning, though B2-receptors do not appear to mediate the ischaemic preconditioning phenomenon itself.
Joel Starkopf (1997) studied this question.
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