Why the study?
Does chronic bradykinin infusion delay the progression of heart failure and preserve vascular endothelium-mediated vasodilation in a canine model of pacing-induced heart failure?
Population
16 instrumented conscious dogs undergoing ventricular pacing (250 bpm, 5 weeks) to induce heart failure
Comparison
Chronic bradykinin infusion through the left… vs Vehicle infusion through the left atria during…
Design
Preclinical, Randomized
Follow-up
5 weeks
Authors
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May attenuate experimental HF progression; leaves open translation to human therapy.
Does chronic bradykinin infusion delay the progression of heart failure and preserve vascular endothelium-mediated vasodilation in a canine model of pacing-induced heart failure?
Chronic bradykinin infusion delays heart failure progression and preserves vascular endothelial function in a canine pacing-induced HF model.
Tonduangu et al. (2003) studied this question.
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