Why the study?
Does bradykinin antagonism with B9340 reduce forearm blood flow in patients with heart failure on chronic ACE inhibitor therapy?
Population
8 healthy volunteers and 17 patients with NYHA grade II through IV heart failure maintained on chronic ACE…
Comparison
Intrabrachial infusion of B9340 at incremental… vs Placebo infusion
Design
RCT, randomized manner, double-blind
Authors
Loading...
Bradykinin mediates ACE inhibitor vasodilation in heart failure; confirms its role in chronic therapy effects but not basal tone.
Does bradykinin antagonism with B9340 reduce forearm blood flow in patients with heart failure on chronic ACE inhibitor therapy?
Bradykinin contributes to the vasodilatory effects of chronic ACE inhibitor therapy in patients with heart failure, but not to basal vascular tone.
Witherow et al. (2001) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: