Why the study?
Does bradykinin affect systemic and pulmonary circulation and venous tone, and are these effects modulated by prostaglandins or ACE inhibitors?
Population
Subjects undergoing investigation of systemic and pulmonary circulation and dorsal hand vein tone
Design
Other
Authors
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ACE inhibitor BP lowering may involve bradykinin potentiation; leaves open endogenous kinin contribution to clinical outcomes.
Does bradykinin affect systemic and pulmonary circulation and venous tone, and are these effects modulated by prostaglandins or ACE inhibitors?
Bradykinin acts as a potent vasodilator in systemic and pulmonary circulations, and its massive potentiation by ACE inhibitors suggests endogenous kinins play a key role in the blood pressure-lowering effects of ACE inhibitors.
Bönner et al. (1992) studied this question.
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