Key result
In the intact-chest cat, serotonin caused dose-related increases in lobar arterial pressure and pulmonary vascular resistance, which were blocked by ketanserin.
Population
Intact-chest cat model
Design
Preclinical
Authors
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Caution against human translation; leaves open S2 receptor targeting in pulmonary vascular research.
In the feline pulmonary vascular bed, serotonin induces vasoconstriction primarily through S2 receptor activation, independent of alpha-1 receptors or thromboxane.
McMahon et al. (1993) studied Pulmonary vascular responses. Serotonin (5-HT) was evaluated on Lobar arterial pressure and pulmonary vascular resistance. In the intact-chest cat, serotonin caused dose-related increases in lobar arterial pressure and pulmonary vascular resistance, which were blocked by ketanserin.
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