Why the study?
Does sympathetic nerve stimulation alter the distensibility and resistance of the pulmonary arterial tree in isolated canine lung lobes?
Population
Canine lung lobes isolated in situ and perfused with a pulsatile pump
Comparison
Sympathetic nerve stimulation (SNS) vs Control (baseline without stimulation)
Design
Preclinical
Authors
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Does not support changes in clinical pulmonary hemodynamic assessment; leaves open sympathetic effects on distensibility in human disease.
Does sympathetic nerve stimulation alter the distensibility and resistance of the pulmonary arterial tree in isolated canine lung lobes?
Sympathetic nerve stimulation decreases the distensibility of large pulmonary arteries and the precapillary bed without changing calculated resistance in a canine model.
Ingram et al. (1968) studied this question.
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