What question did this study set out to answer?

The aim is to understand how cardiac sympathetic nerve stimulation affects the right ventricle compared to the left ventricle in dogs.

January 1, 1987Japanese Circulation Journal-english EditionOpen Access

The effect of cardiac sympathetic nerve stimulation on the right ventricle in canine heart.

View Full Paper

Ask AI

Bookmark

Population

Anesthetized open chest dogs

Comparison

Right or left cardiac sympathetic nerve… vs Baseline/controls

Design

Preclinical

Authors

YAYukihiro AbeSantec Systems (United States)DSDaiji SaitoCity Hospital HTHideki TaniGifu Municipal Hospital

Discussion

Member takes

Implication

Greater RV workload response to sympathetic stimulation in dogs; leaves open human translation and therapeutic implications.

Key Points

The aim is to understand how cardiac sympathetic nerve stimulation affects the right ventricle compared to the left ventricle in dogs.
Studied anesthetized open chest dogs for hemodynamic changes due to sympathetic nerve stimulation.
Measured coronary blood flow rates in right coronary artery and left anterior descending coronary artery.
Examined effects of phentolamine and isoproterenol infusion on hemodynamics.
Right ventricular systolic pressure X heart rate (RVSP X HR) increased more than left ventricle under sympathetic stimulation.
Phentolamine did not alter the response to sympathetic stimulation compared to controls.
Isoproterenol infusion showed no difference in coronary blood flow increase between RCA and LAD.

Structured PICO

Population

Anesthetized open chest dogs

Intervention

Right or left cardiac sympathetic nerve stimulation (with or without phentolamine injection) and beta-stimulation by isoproterenol infusion

Comparator

Baseline/controls

Outcome

Change in coronary hemodynamics (mean coronary blood flow in right coronary artery and left anterior descending coronary artery, and right ventricular systolic pressure X heart rate)surrogate

Cardiac sympathetic nerve stimulation has a greater effect on the right ventricle's oxygen demand compared to the left ventricle, primarily mediated by beta-adrenoceptors.

Cite This Study

Abe et al. (1987) studied this question.

synapsesocial.com/papers/6a73072c9cd4de638c9a336d https://doi.org/10.1253/jcj.51.535

View Full Paper

Ask AI

Bookmark

The effect of cardiac sympathetic nerve stimulation on the right ventricle in canine heart.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

The effect of cardiac sympathetic nerve stimulation on the right ventricle in canine heart.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider