January 1, 1998Japanese Circulation Journal-english EditionOpen Access

Cardiac Sympathetic Stimulation Increases Cardiac Contractility But Decreases Contractile Efficiency in Canine Hearts In Vivo

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Population

19 anesthetized and open-chest dogs

Comparison

Cardiac sympathetic stimulation with and without… vs Baseline (before sympathetic stimulation)

Design

Preclinical

Authors

TKTakeshi KudoKanazawa University AMAtsushi MikuniyaHirosaki University NSNaoyuki SutoAomori Rosai Hospital

Discussion

Member takes

Implication

Sympathetic effects on efficiency in this model; leaves open translation to human HF energetics.

Structured PICO

Population

19 anesthetized and open-chest dogs

Intervention

Cardiac sympathetic stimulation (9V, 6 Hz, 40 sec) with and without 50 mg/kg of 2,3-butanedione monoxime (BDM)

Comparator

Baseline (before sympathetic stimulation)

Outcome

Left ventricular end-systolic pressure volume relations (ESPVR) and the relation between myocardial oxygen consumption (VO2)-pressure volume area (PVA)surrogate

Cardiac sympathetic stimulation decreases cardiac contractile efficiency by enhancing myosin ATPase-operating ATP hydrolysis in crossbridge formation.

Cite This Study

Kudo et al. (1998) studied this question.

synapsesocial.com/papers/6a71b60ae36a167817e37150 https://doi.org/10.1253/jcj.62.925

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Cardiac Sympathetic Stimulation Increases Cardiac Contractility But Decreases Contractile Efficiency in Canine Hearts In Vivo

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cardiac Sympathetic Stimulation Increases Cardiac Contractility But Decreases Contractile Efficiency in Canine Hearts In Vivo

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider