What does this research mean for the field?

Cardiac sympathetic nerve stimulation increases coronary inflow primarily through augmented diastolic flow and potential arteriolar dilatation, though an initial transient reduction suggests a primary direct vasoconstrictive effect. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The aim was to investigate the effects of cardiac sympathetic nerve stimulation on coronary inflow in dogs.

February 1, 1965Circulation ResearchOpen Access

Coronary Inflow and Oxygen Usage Following Cardiac Sympathetic Nerve Stimulation in Unanesthetized Dogs

View Full Paper

Ask AI

Bookmark

Why the study?

Does cardiac sympathetic nerve stimulation affect coronary inflow in conscious dogs?

Population

Previously operated conscious dogs

Design

Preclinical

Authors

LGLino GranataWalter Reed Army Institute of Research RORay A. OlssonForschungszentrum Jülich AHAndrew G. HuvosMemorial Sloan Kettering Cancer Center

Discussion

Member takes

Implication

Requires human validation before any clinical consideration; extends preclinical models of sympathetic coronary regulation.

Key Points

The aim was to investigate the effects of cardiac sympathetic nerve stimulation on coronary inflow in dogs.
Used electromagnetic flowmeters to measure coronary inflow in conscious dogs.
Examined changes in inflow during diastole and systole under varying stimulation strengths.
Coronary inflow increased primarily during diastole, indicating enhanced blood flow.
Systolic inflow changes were less consistent and varied with stimulation strength.
Some instances showed initial vasoconstriction followed by increased inflow, suggesting complex vascular responses.

Structured PICO

Does cardiac sympathetic nerve stimulation affect coronary inflow in conscious dogs?

Population

Previously operated conscious dogs

Intervention

Cardiac sympathetic nerve stimulation

Outcome

Coronary inflow measured using electromagnetic flowmeterssurrogate

Cardiac sympathetic nerve stimulation in conscious dogs increases coronary inflow primarily during diastole, potentially mediated by arteriolar dilatation.

Cite This Study

Granata et al. (1965) studied this question.

synapsesocial.com/papers/6a1c838594dbf6307b2fdd02 https://doi.org/10.1161/01.res.16.2.114

View Full Paper

Ask AI

Bookmark

Coronary Inflow and Oxygen Usage Following Cardiac Sympathetic Nerve Stimulation in Unanesthetized Dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Coronary Inflow and Oxygen Usage Following Cardiac Sympathetic Nerve Stimulation in Unanesthetized Dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider