What does this research mean for the field?

Electrical stimulation of the carotid sinus nerves in conscious dogs produces a differential pattern of peripheral vasodilatation, with the most profound dilatation occurring in the hind-limb circulation, both at rest and during exercise. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To determine the effects of carotid sinus nerve stimulation on cardiac output distribution and regional vascular resistance in conscious dogs at rest and during treadmill exercise.

October 1, 1970Circulation Research

Effects of Carotid Sinus Nerve Stimulation on Blood-Flow Distribution in Conscious Dogs at Rest and during Exercise

View Full Paper

Ask AI

Bookmark

Why the study?

Does carotid sinus nerve stimulation alter blood-flow distribution and peripheral vasoactivity in conscious dogs at rest and during exercise?

Population

Intact, unanesthetized dogs instrumented with ultrasonic or electromagnetic flow probes on the ascending…

Comparison

Carotid sinus nerve stimulation using a… vs Baseline/control values prior to stimulation

Design

Preclinical

Authors

SVStephen F. VatnerHeart Failure & Transplant DFDean FranklinUniversity of Leeds RCRobert L. Van CittersNational Institutes of Health

Discussion

Member takes

Implication

Supports exploration of baroreflex neuromodulation; leaves open translation from conscious canine models to human therapy.

Key Points

To determine the effects of carotid sinus nerve stimulation on cardiac output distribution and regional vascular resistance in conscious dogs at rest and during treadmill exercise.
Conscious dogs were chronically instrumented with flow probes on the ascending aorta, mesenteric, renal, and iliac arteries, alongside miniature aortic pressure gauges.
Carotid sinus nerves were stimulated for 30-second intervals using a radiofrequency pacemaker at rest, during treadmill exercise, and after autonomic blockade.
In resting dogs, stimulation caused a 28% reduction in aortic pressure and a 29% fall in total peripheral resistance with unchanged cardiac output; iliac flow rose by 90% and iliac resistance fell by 62%.
Mesenteric and renal resistances decreased by 18% and 22% (with flow dropping by 12% and 8%, respectively), alongside an initial 13% vagally mediated reduction in heart rate.
During exercise, nerve stimulation induced comparable decreases in arterial pressure and visceral resistance, triggering further iliac vasodilation beyond metabolic exercise baselines.

Structured PICO

Does carotid sinus nerve stimulation alter blood-flow distribution and peripheral vasoactivity in conscious dogs at rest and during exercise?

Population

Intact, unanesthetized dogs instrumented with ultrasonic or electromagnetic flow probes on the ascending aorta, mesenteric, renal, and iliac arteries, and miniature pressure gauges in the aorta

Intervention

Carotid sinus nerve stimulation using a radiofrequency pacemaker for 30-second periods at rest, during treadmill exercise, and after autonomic blockade

Comparator

Baseline/control values prior to stimulation

Outcome

Changes in aortic pressure, cardiac output, total peripheral resistance, and regional blood flow and vascular resistance (mesenteric, renal, iliac)surrogate

Carotid sinus nerve stimulation in conscious dogs produces differential peripheral vasodilatation, most profoundly in the hind-limb circulation, which persists even during exercise.

Cite This Study

Vatner et al. (1970) studied this question.

synapsesocial.com/papers/6a19bb70443d3ecd7cdef1ef https://doi.org/10.1161/01.res.27.4.495

View Full Paper

Ask AI

Bookmark

Effects of Carotid Sinus Nerve Stimulation on Blood-Flow Distribution in Conscious Dogs at Rest and during Exercise

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Effects of Carotid Sinus Nerve Stimulation on Blood-Flow Distribution in Conscious Dogs at Rest and during Exercise

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider