Why the study?
Does increasing carotid sinus pressure reduce renal vasoconstrictor responses to angiotensin and norepinephrine in anesthetized dogs?
Population
Dogs anesthetized with morphine and chloralose, with kidneys and one or both carotid sinuses perfused at a…
Comparison
Maximal carotid sinus pressure vs Lower carotid sinus pressure
Design
Preclinical
Authors
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Highlights humoral baroreflex-renal interaction in dogs; leaves open translation to human hypertension or HF.
Does increasing carotid sinus pressure reduce renal vasoconstrictor responses to angiotensin and norepinephrine in anesthetized dogs?
Increasing carotid sinus pressure reduces renal vasoconstrictor responses to angiotensin and norepinephrine via a bloodborne substance independent of renal sympathetic nerves.
Geller et al. (1967) studied this question.
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