January 1, 1976American Journal of Physiology-Legacy Content
Interplay among carotid sinus, cardiopulmonary, and carotid body reflexes in dogs
Key result
The carotid sinus reflex plays a dominant role when interacting with cardiopulmonary and carotid body reflexes, rendering chemoreceptor stimulation ineffective when inhibition is maximal.
Population
Anesthetized, atropinized, and respired dogs with aortic nerves cut
Comparison
Carotid sinus perfusion at 220, 150, and 40-50… vs Varying levels of sinus pressure and blood volume
Design
Preclinical
Authors
Discussion
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Implication
Carotid sinus dominance in animal reflex models warrants caution against clinical extrapolation; leaves open human baroreflex hierarchy studies.
Structured PICO
P
Population
Anesthetized, atropinized, and respired dogs with aortic nerves cut undergoing physiological reflex testing.
I
Intervention
Carotid sinus perfusion at 220, 150, and 40-50 mmHg; chemoreceptor stimulation by perfusion with hypoxic hypercapnic blood; interruption of cardiopulmonary vasomotor inhibition by vagal cold block
C
Comparator
Varying levels of sinus pressure and blood volume
O
Outcome
Arterial blood pressure and kidney and hindlimb vascular resistancesurrogate
This preclinical study demonstrates the dominant role of the carotid sinus reflex over cardiopulmonary and carotid body reflexes in regulating vascular resistance.
Cite This Study
Mancia et al. (1976) studied this question. Carotid sinus perfusion, chemoreceptor stimulation, and vagal cold block was evaluated on Arterial blood pressure and kidney and hindlimb vascular resistance. The carotid sinus reflex plays a dominant role when interacting with cardiopulmonary and carotid body reflexes, rendering chemoreceptor stimulation ineffective when inhibition is maximal.