Key result
Interruption of cardiopulmonary vagal afferents potentiated vascular and ventilatory responses to carotid chemoreceptor activation and augmented carotid baroreceptor reflex gain at low pressures.
Why the study?
Does the interruption of cardiopulmonary vagal afferents modulate carotid chemoreceptor and baroreceptor reflexes in dogs?
Population
Anesthetized, ventilated dogs and spontaneously breathing dogs prepared with cut aortic nerves, cut cervical…
Comparison
Interruption of cardiopulmonary vagal afferents. vs Intact cardiopulmonary vagal afferents.
Design
Preclinical
Authors
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Vagal modulation of carotid reflexes in dogs leaves open any role in human baroreflex or chemoreflex control; human studies required.
Does the interruption of cardiopulmonary vagal afferents modulate carotid chemoreceptor and baroreceptor reflexes in dogs?
Physiological levels of cardiopulmonary vagal afferent impulses suppress carotid baroreceptor and chemoreceptor reflexes through central nervous system interaction.
Koike et al. (1975) studied this question. Interruption of cardiopulmonary vagal afferents (vagotomy) vs. Intact vagal afferents (baseline) was evaluated on Reflex vascular and ventilatory responses to activation of carotid chemoreceptors and baroreceptors. Interruption of cardiopulmonary vagal afferents potentiated vascular and ventilatory responses to carotid chemoreceptor activation and augmented carotid baroreceptor reflex gain at low pressures.
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