Key result
Carotid chemoreceptor stimulation with nicotine elicits sympathetically mediated cerebral vasoconstriction in conscious dogs.
Population
Conscious dogs (n=18 intact, n=9 bilateral cervical sympathectomy, n=6 sham)
Comparison
Carotid chemoreceptor reflex stimulation via… vs Bilateral cervical sympathectomy vs intact/sham…
Design
Preclinical
Authors
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Requires caution before clinical translation; leaves open whether chemoreflex sympathetic vasoconstriction occurs in human cerebral vessels.
p-value: p=<0.01
Stimulation of the carotid chemoreceptor reflex elicits significant sympathetically mediated vasoconstriction in cerebral vessels in conscious dogs.
Vatner et al. (1980) studied this question. Carotid chemoreceptor reflex stimulation (intracarotid injection of nicotine) vs. Bilateral cervical sympathectomy / sham was evaluated on Cerebral blood flow and cerebral vascular resistance (p=<0.01). Carotid chemoreceptor reflex stimulation with nicotine elicited significant sympathetically mediated vasoconstriction in cerebral vessels in conscious dogs.
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