March 1, 1964American Journal of Physiology-Legacy Content
Carotid chemoreceptor reflex effects on coronary flow and heart rate
Population
Innervated Langendorff's dog heart preparation in ventricular fibrillation with completely separated cross…
Design
Preclinical
Authors
Discussion
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Implication
May inform autonomic coronary control in models; leaves open human translation of chemoreflex effects.
Structured PICO
P
Population
Innervated Langendorff's dog heart preparation in ventricular fibrillation with completely separated cross circulations to the head and heart
I
Intervention
Carotid chemoreceptor reflex induction (via nicotine, lobeline, 5-hydroxytryptamine, acetylcholine), atropinization, and temperature modulation (31 C to 40 C)
O
Outcome
Atrial rhythm and coronary blood flow at constant pressuresurrogate
This preclinical study demonstrates that the carotid chemoreceptor reflex exerts both vagal coronary dilator and sympathetic coronary constrictor effects in the dog heart.
Cite This Study
Hashimoto et al. (1964) studied this question.