Key result
Carotid body stimulation raises coronary blood flow via higher systemic pressure, not cardiac sympathetic activity.
Why the study?
Does selective hypoxic and/or hypercapnic carotid chemoreceptor stimulation alter coronary vascular resistance and myocardial function in anesthetized dogs?
Population
Constantly ventilated, pentobarbital or urethan-chloralose anesthetized dogs
Design
Preclinical
Authors
Loading...
May caution against assuming direct sympathetic coronary effects from carotid chemoreceptor activation; animal data leaves open human relevance.
Does selective hypoxic and/or hypercapnic carotid chemoreceptor stimulation alter coronary vascular resistance and myocardial function in anesthetized dogs?
Local carotid body stimulation increases coronary blood flow primarily through an increase in systemic arterial pressure, rather than direct sympathetic activation of the heart.
Ehrhart et al. (1975) studied this question. Selective hypoxic and/or hypercapnic carotid chemoreceptor stimulation was evaluated on Coronary vascular resistance, left ventricular dP/dt, and strain-gauge arch output. Local carotid body stimulation increased coronary blood flow mainly via increased systemic arterial pressure, providing little evidence for increased sympathetic activity of the heart.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: